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  • Title: The effect of a beta-adrenergic agent on prostaglandin stimulated labor.
    Author: Scher J, Baillie P.
    Journal: Adv Biosci; 1973; 9():743-9. PubMed ID: 4156848.
    Abstract:
    This study examines the effect of beta-adrenergic administration (orciprenaline) on oxytocin- and prostaglandin-induced uterine activity at term in 10 patients in whom labor was induced. An amniocentesis was performed and Pethidine 50 mg was administered intravenously. Labor was induced by oxytocin or prostaglandin F2alpha (PGF2alpha) using a constant-rate infusion pump. When uterine activity was compatible with early labor, 0.25 mg of orciprenaline was administered. When the uterine activity returned to the original level, the 1st drug was discontinued and the other substituted. When the membranes were ruptured, labor was allowed to continue. All cases were delivered vaginally within 18 hours. Results show that: 1) there is no difference in the effect of orciprenaline on the cardiovascular variables, pulse rate, and blood pressure when labor was induced with PGF2 alpha and oxytocin; 2) maternal tachycardia and an increase in pulse pressure were noted in all cases; 3) there was no alpha adrenergic effect of the PG at the dosage used; and 4) uterine activity was abolished for a longer period when the contractions were induced by oxytocin in spite of an initial higher level of uterine activity in the PG series. Orciprenaline, a resorcyl ethanolamine and beta-adrenergic stimulant, was less effective in decreasing uterine activity stimulated by PGF2alpha than by oxytocin. These findings conform with the hypothesis that PGs may be implicated in the stage of rapid cervical dilation, as beta-adrenergics are known to be less effective in this stage of premature labor. A new approach is suggested in that antiprostaglandins may be effective at a later stage in premature labor.
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