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  • Title: [The evidence capacity of the lymphocyte-transformation-test and the quantitative immunoglobulin-determination in sarcoidosis (author's transl)].
    Author: Zochert J, Thomas U, Bösel B.
    Journal: Z Erkr Atmungsorgane; 1977 Aug; 149(2):243-6. PubMed ID: 416607.
    Abstract:
    In 50 patients suffering from a cytologically or histologically confirmed sarcoidosis the unspecific transformation rate by PHA in the lymphocyte-transformation-test (LTT) and the immunoglobulins IgA, IgG, IgM and IgD have been determined by the help of a simple radial immunodiffusion. The evaluation of the LTT took place morphologically. 600 cells were counted each set-up (3 different smears each PHA-set-up). For the purpose of a better morphological presentation of lymphoblasts in the LTT a smear of alkalineous hydrolysis was fixed and followed by a colouring according to PAPPENHEIM. There was a decreased PHA-transformation-rate in sarcoidosis as a symptom for a partial defect within the cellular immune area. The levels of immunoglobulins showed no deviations as against to standard values.
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