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  • Title: Mode of action of anti-lymphocyte globulin. I. The distribution of rabbit anti-lymphocyte globulin injected into rats and mice.
    Author: Denman AM, Frenkel EP.
    Journal: Immunology; 1968 Jan; 14(1):107-13. PubMed ID: 4169721.
    Abstract:
    The distribution of rabbit anti-lymphocyte globulin (IgG) following injection into rats and mice has been studied by immunofluorescence and 131I labelling, and the tissues from treated animals have been examined by electron-microscopy. The results suggest that the anti-lymphocyte globulin reacts primarily with circulating lymphocytes, and that it penetrates the thymus, spleen and lymph nodes to a limited extent. These findings may explain the selective immuno-suppressive action of anti-lymphocyte globulin.
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