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  • Title: The effect of acetylsalicyclic acid on platelet function.
    Author: Evans G, Packham MA, Nishizawa EE, Mustard JF, Murphy EA.
    Journal: J Exp Med; 1968 Nov 01; 128(5):877-94. PubMed ID: 4176225.
    Abstract:
    Acetylsalicylic acid (ASA, aspirin) and sodium salicylate inhibit platelet aggregation induced by collagen, antigen-antibody complexes, gamma globulin-coated particles or thrombin. These compounds suppress the release of platelet constituents, such as adenosine diphosphate (ADP) and serotonin, induced by such stimuli. Since ASA and sodium salicylate do not inhibit ADP-induced platelet aggregation, it appears that their effect on the action of the other stimuli is due to a decrease in the amount of ADP released. The administration of ASA to rabbits (in doses which inhibited collagen-induced platelet aggregation) impaired hemostasis, prolonged platelet survival, and diminished the amount of deposit formed in an extracorporeal shunt.
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