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  • Title: The immune response suppressed by specific antibody.
    Author: Rowley DA, Fitch FW, Axelrad MA, Pierce CW.
    Journal: Immunology; 1969 Apr; 16(4):549-59. PubMed ID: 4181542.
    Abstract:
    Homologous or heterologous anti-sheep erythrocyte serum given passively to normal rats markedly suppressed their spleen plaque-forming cell and serum antibody response to sheep erythrocytes. Passive immunization against bovine γ-globulin prevented `sensitization' by a first injection of the antigen. The suppressive effect of passive antibody was prevented or partially prevented by adjuvants, B. pertussis vaccine, S. typhi endotoxin or Freund's complete adjuvant. Passive antibody or adjuvants had relatively little effect on the primary response when given more than 24 hours after antigen or on the secondary response when given with antigen. The kinetics of the early spleen plaque-forming cell response were measured using sheep erythrocytes as antigen, homologous anti-sheep erythrocyte serum for passive immunization and B. pertussis vaccine as adjuvant. With a constant antigen dose, larger amounts of passive antibody caused increased suppression. Suppression apparently resulted from a decrease in the number of cells initially responding; the rate of proliferation of cells that did respond was not affected by passive antibody. If the amount of passive antibody was kept constant, an increase in antigen dose or addition of adjuvant to the antigen increased the rate of proliferation of the cells that did respond; an effect sufficient to completely mask suppression produced by smaller amounts of passive antibody. These findings can be accounted for by assuming that passive antibody and higher antigen doses or adjuvant affect different interactions required for the antibody response. Thus, the magnitude of the antibody response is dependent not only on the amounts of antigen and passively given antibody but also on the amount and activity of any intentionally or unintentionally introduced factor having adjuvant activity.
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