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  • Title: Attenuation of stereotyped behaviour by sex steroids.
    Author: Naik SR, Kelkar MR, Sheth UK.
    Journal: Psychopharmacology (Berl); 1978 Apr 28; 57(2):211-4. PubMed ID: 418456.
    Abstract:
    Effects of sex steroids, testosterone, progesterone, and estradiol on PEA-induced stereotyped behaviour (SB) has been studied in normal, castrated, and ovariectomised mice. Effects of sex steroids on amphetamine-induced sterotypy and hyperactivity are also described. In castrated and ovariectomised mice B-phenylethylamine (PEA) increased SB. Pretreatment with sex steroids attenuated PEA-induced stereotypy in normal, castrated, and ovarietomised mice. Sex steroid pretreatment significantly inhibited PEA- and amphetamine-induced SB, but failed to alter increased motor activity due to amphetamine or PEA. The possible effect of sec steroids on SB through changes in central neurotransmitters are discussed.
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