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  • Title: Clinical evaluation of Rho(D) immune globulin (human) in Canada.
    Author: Bryant EC, Hart GD, Cairns D, Gamarra JA, de Veber LL, Holland CG, Hutchison JL.
    Journal: Can Med Assoc J; 1969 Dec 13; 101(12):82-3. PubMed ID: 4188450.
    Abstract:
    -During 1966, clinical trials were conducted in three Canadian centres to determine the safety and efficacy of Rh(0)(D) immune globulin (human) in preventing isoimmunization by the Rh(0)(D) antigen in Rh-negative women delivering ABO-compatible Rh-positive infants.The candidates were randomly divided into control and treated groups; the treated mothers received an intramuscular injection of 300 mug. of anti-Rh(0)(D) within 72 hours of delivery. Follow-up antibody screening tests were conducted on the sera of all patients six to nine months post partum.Of the 175 control patients, 11 or 6.2% became actively immunized to the Rh antigen, whereas complete protection against maternal Rh immunization was observed in the 191 treated patients.
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