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  • Title: Monoamine oxidase inhibition and brain amine metabolism after oral treatment with toloxatone in the rat.
    Author: Keane PE, Kan JP, Sontag N, Benedetti MS.
    Journal: J Pharm Pharmacol; 1979 Nov; 31(11):752-4. PubMed ID: 41906.
    Abstract:
    Rats were administered toloxatone 100 mg kg-1 p.o., and killed 0.5 to 8 hours later. Toloxatone reversibly inhibited type A MAO, but did not affect the activity of type B MAO in whole brain. Cerebral concentrations of noradrenaline, dopamine and 5-hydroxytryptamine were increased after toloxatone, while their metabolite concentrations were reduced. Synaptosomal uptake processes of these amines were not altered by tolaxatone.
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