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  • Title: Sexual differentiation of pituitary function: apparent difference bewteen primates and rodents.
    Author: Karsch FJ, Dierschke DJ, Knobil E.
    Journal: Science; 1973 Feb 02; 179(4072):484-6. PubMed ID: 4196168.
    Abstract:
    Surges in luteinizing hormone secretion resembling those which occur spontaneously during the menstrual cycle were induced by acute elevations in circulating estrogen concentrations in both male and female rhesus monkeys gonadectomized in adulthood. These experiments demonstrate that in primates, in contrast to rodents, exposure of the hypothalamohypophyseal unit to androgens throughout fetal and postnatal development does not prevent the differentiation of the control system that governs cyclic gonadotropin secretion.
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