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  • Title: Antigenic variation in current human type A influenza viruses: antigenic characteristics of the variants and their geographic distribution.
    Author: Schild GC, Henry-Aymard M, Pereira MS, Chakraverty P, Dowdle W, Coleman M, Chang WK.
    Journal: Bull World Health Organ; 1973; 48(3):269-78. PubMed ID: 4200741.
    Abstract:
    Outbreaks of influenza due to the virus A/Hong Kong/1/68 (H3N2) began in 1968 and are still occurring. The haemagglutinin of this virus is different from that of the A/Singapore/1/57 virus (the "Asian" strain) but the neuraminidase antigens are the same. Between 1968 and 1971 only minor antigenic "drift" in the haemagglutinin was noted, but in recent months 2 isolates have been identified in which considerable "drift" has occurred in the haemagglutinin and in the neuraminidase antigens. One, A/Hong Kong/5/72 (H3N2), was first detected in outbreaks in Hong Kong between November 1971 and January 1972 and was predominant there and in Korea but did not become widely disseminated. The second strain, A/England/42/72 (H3N2), has been isolated in winter outbreaks in the southern hemisphere and now appears to be the predominant strain in the northern hemisphere. The characteristics of the strains are described.
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