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  • Title: Unequal mitotic sister chromatin exchange as the mechanism of ribosomal RNA gene magnification.
    Author: Tartof KD.
    Journal: Proc Natl Acad Sci U S A; 1974 Apr; 71(4):1272-6. PubMed ID: 4208547.
    Abstract:
    It is hypothesized that magnification of the gene coding for ribosomal RNA occurs by unequal mitotic sister chromatid exchange on the basis of five different lines of evidence. These are: (1) rDNA magnification occurs in mitotically active germ cells; (2) decreases in rDNA redundancy can be genetically produced, a phenomenon termed reduction; (3) magnification and reduction events are reversible and reciprocal; (4) it is possible to generate bb(+) and bb somatic bristle mosaics (bb mutants are partially deficient for rRNA genes); and (5) magnification of bb in a ring X chromosome is reduced. Implications of these results and the unequal sister exchange (USE) hypothesis are discussed.
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