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  • Title: The effect of morphine pretreatment on hypothermia induced by morphine in mice.
    Author: Wong CL, Bentley GA.
    Journal: Eur J Pharmacol; 1979 Feb 01; 53(4):391-4. PubMed ID: 421732.
    Abstract:
    Morphine caused an apparently dose-dependent hypothermia in mice. Co-administration of naloxone antagonised this effect. Pretreatment with a single dose of morphine induced detectable tolerance to the hypothermic effect of a second dose of morphine given 3 h later and naloxone was more effective in antagonising the hypothermic effect of morphine in morphine-pretreated mice than in saline-pretreated animals. The present study has shown that morphine pretreatment can augment the antagonistic effect of naloxone towards the hypothermic action of morphine.
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