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  • Title: Synthesis and pharmacology of a prohormone angiotensin antagonist.
    Author: Chiu AT, Sutherland JC, Day AR, Freer RJ.
    Journal: Eur J Pharmacol; 1979 Feb 15; 54(1-2):177-80. PubMed ID: 421740.
    Abstract:
    A prohormone angiotensin antagonist, Sarcosyl1-Alanyl8-angiotensin I (Sar1-Ala8-A-I) was synthesized and its pharmacological properties were evaluated in three biological systems. It was found to be a good inhibitor in vivo in the rat blood pressure assay, somewhat less active in guinea pig ileum and a relatively weak antagonist in rat uterus. In vivo the inhibitory effect was greatly attenuated by the presence of the converting enzyme inhibitor BPP5alpha.
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