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  • Title: The inhibition of human placental diamine oxidase by substrate analogues.
    Author: Crabbe MJ, Bradsley WG.
    Journal: Biochem J; 1974 Apr; 139(1):183-9. PubMed ID: 4219138.
    Abstract:
    1. The oxidation of p-dimethylaminomethylbenzylamine by purified placental diamine oxidase was followed by measuring the change in E(250) caused by the production of p-dimethylaminomethylbenzaldehyde. 2. The inhibition of this reaction by substrate analogues such as isothiouronium, guanidinium, dimethylsulphonium and trimethylammonium compounds was extensively studied. 3. The type and degree of inhibition by mono- and bis-onium compounds is described, and a theory is developed to explain the type of inhibition produced.
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