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  • Title: Ovarian steroid hormones and cerebral function.
    Author: Cogen PH, Zimmerman EA.
    Journal: Adv Neurol; 1979; 26():123-33. PubMed ID: 42283.
    Abstract:
    This study reviews the available literature concerning clinical evidence of the effects of ovarian steroid hormones on the brain. The negative effects of estrogen on chorea gravidarum and in women using oral contraception (OC) is well known. Estrogens, however, can at times be beneficial in patients with movement disorders. The fall of progesterone level at menstruation can be associated with catamenial epilepsy, while estrogen increases epileptiform electroencephalogram activity. Both estrogens and progesterone affect neurotransmitters by altering absolute concentration and turnover in brain tissue. By interfering with monoamine oxidase, estrogens may increase dopamine, and it is possible that they can worsen brain pseudotumor, although data available are not very clear on this point. The possible role of ovarian or male steroid hormones in other neurological disorders is unknown. Further studies are needed, since it is apparent that not all types of abnormal movements respond in the same way to treatment with such steroids.
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