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  • Title: On the regulation of tryptophan metabolism "via" kynurenine.
    Author: Shibata Y.
    Journal: Acta Vitaminol Enzymol; 1978; 32(5-6):195-207. PubMed ID: 42292.
    Abstract:
    The tryptophan leads to nicotinic acid pathway is inhibited in the nicotinic acid administered rats; in this case tryptophan chiefly metabolizes "via" serotonin. The serotonin pathway is inhibited in the excess phenylalanine administered rats, especially due to the inhibition of the tryptophan-5-hydroxylase reaction. Xanthurenic acid inhibits kynurenine-3-hydroxylase in vitro, which is a very important regulatory enzyme for xanthurenic acid and nicotinic acid production.
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