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  • Title: Hurler and Hunter syndromes: mutual correction of the defect in cultured fibroblasts.
    Author: Fratantoni JC, Hall CW, Neufeld EF.
    Journal: Science; 1968 Nov 01; 162(3853):570-2. PubMed ID: 4236721.
    Abstract:
    The biochemical defect of cultuired skin fibroblasts from Hurler or Hunter patients (faulty degradation of sulfated mucopolysaccharide, resulting in excessive intracellular accumulation) may be corrected if cells of these two genotypes are mixed with each other or with normal cells. The effect is mediated by substances released into the medium.
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