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  • Title: Circadian rhythm of serotonin N-acetyltransferase activity in organ culture of chicken pineal gland.
    Author: Deguchi T.
    Journal: Science; 1979 Mar 23; 203(4386):1245-7. PubMed ID: 424750.
    Abstract:
    When chicken pineal glands were organ-cultured in darkness, serotonin N-acetyltransferase activity was low during daytime, increased at midnight, and decreased on the next morning. The autonomous increase of N-acetyltransferase activity was suppressed by illumination of the glands. When pineal glands were cultured under a light-dark cycle (LD 12:12), the change of N-acetyltransferase activity continued to oscillate in phase with the light-dark cycle for 3 days.
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