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  • Title: Biochemical changes in liver due to aflatoxin.
    Author: Shankaran P, Shankaran R, Raj HG, Venkitasubramanian TA.
    Journal: Br J Exp Pathol; 1970 Oct; 51(5):487-91. PubMed ID: 4250035.
    Abstract:
    The effect of a single dose of aflatoxin on the content of glycogen, lipid and protein of mouse liver was studied 2 hr after injection of the toxin but no significant change was observed. Enzymes in liver of mice were assayed 2 hr and 8 hr after aflatoxin treatment. In general, the enzymes of particulate fraction and isocitrate dehydrogenase in the supernatant showed a significant increase; the remaining enzymes of the supernatant fraction decreased at both time intervals. The response of the activities of aconitase, fumarase and ATP-ase 2 hr after injection were the opposite of those at 8 hr. The results are explicable in terms of mitochondrial injury of the aflatoxin-treated animals.
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