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  • Title: Hypnotic efficacy of lorazepam and flurazepam.
    Author: Wang RI, Stockdale SL, Hieb E.
    Journal: Clin Pharmacol Ther; 1976 Feb; 19(2):191-5. PubMed ID: 4255.
    Abstract:
    In a double-blind crossover study involving 15 insomniac subjects, the hypnotic efficacy of lorazepam, 2 and 4 mg, was compared with flurazepam, 15 and 30 mg, and placebo. Five subjective measures were used: onset, length, and depth of sleep, number of times awakened, and satisfaction with the hypnotic. Lorazepam in 2- and 4-mg doses was comparable in hypnotic efficacy to flurazepam, 30 mg, according to most parameters of measurement. Side effects were minor, although relatively numerous at the 4-mg doses.
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