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  • Title: [Results of a long-term clomiphene citrate therapy in women with normogonadotropic menstrual disturbanes (author's transl)].
    Author: Schmid R, Leodolter S, Müller-Tyl E, Philipp K, Schneider WH.
    Journal: Wien Klin Wochenschr; 1979 Feb 16; 91(4):122-5. PubMed ID: 425531.
    Abstract:
    A total of 72 pregnancies was achieved in 59 women with menstrual cycle disturbances (WHO Type II) by administration of clomiphene. 27 of these pregnancies (34.7%) occurred only after more than three courses of cloimphene. A secondary classification of the patients was based on the symptomatic severity of the menstrual disturbance. Clomiphene (100 mg) was administered on the fifth day after the onset of menstruation for five days, whereby in one or two cases up to 19 courses had to be given. The group consisted of women who had rejected HMG-HCG therapy because of the possibility of multiple pregnancy. 59 pregnancies went to full term; 2 tubal pregnancies and 11 cases of miscarriage were recorded. The commencement of pregnancy was evaluated and the time of ovulation and the length of the luteal phase determined in women requiring up to three courses of clomiphene and those requiring over three courses. The investigation demonstrates that clomiphene therapy can be successful even after more than six courses of the drug. Side effects are minimal.
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