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  • Title: Informational DNA synthesis distinguished from that of nuclear DNA by inhibitors of DNA synthesis.
    Author: Bell E.
    Journal: Science; 1971 Nov 05; 174(4009):603-6. PubMed ID: 4255943.
    Abstract:
    With inhibitors of DNA synthesis used in the presence of ethidium bromide, it has been possible to distinguish between synthesis of informational DNA (I-DNA) and that of nuclear DNA. Hydroxyurea depresses I-DNA synthesis preferentially but does not affect DNA transport between cell compartments. 5-Fluorodeoxyuridine and cytosine arabinoside reduce synthesis of I-DNA to a much lesser degree than that of nuclear DNA.
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