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  • Title: The defect in the Hurler and Scheie syndromes: deficiency of -L-iduronidase.
    Author: Bach G, Friedman R, Weissmann B, Neufeld EF.
    Journal: Proc Natl Acad Sci U S A; 1972 Aug; 69(8):2048-51. PubMed ID: 4262258.
    Abstract:
    Skin fibroblasts cultured from patients affected with the Hurler or Scheie syndromes (mucopoly-saccharidoses I or V, respectively) have a functional deficiency of a protein required for catabolism of sulfated mucopolysaccharide that has been designated the "Hurler corrective factor." We now show Hurler factor purified from normal human urine to be associated with alpha-L-iduronidase activity. Cell lines deficient in Hurler corrective factor have no detectable activity of alpha-L-iduronidase (less than 3% of that found in cells from individuals of other genotypes). Such correspondence indicates that Hurler corrective factor and alpha-L-iduronidase are the same entity. Correction of deficient cells is accompanied by an efficient uptake of alpha-L-iduronidase from the medium.
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