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  • Title: Activation of membrane-bound adenylate cyclase by glucagon in Neurospora crassa.
    Author: Flawiá MM, Torres HN.
    Journal: Proc Natl Acad Sci U S A; 1972 Oct; 69(10):2870-3. PubMed ID: 4263508.
    Abstract:
    Membrane-bound adenylate cyclase in Neurospora crassa is activated by glucagon. Half-maximal effect is observed at hormone concentrations of about 10 nM. After solubilization of the enzyme with Lubrol-PX, the glucagon effect is lost. Incubation of neurospora cells with glucagon leads to a decrease in the activity of glycogen synthetase (EC 2.4.1.11) and to an increase in the activity of glycogen phosphorylase (EC 2.4.1.1) and in the rate of glycogenolysis.
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