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  • Title: Intravenous use of cephradine and cefazolin against serious infections.
    Author: Caloza DL, Semar RW, Bernfeld GE.
    Journal: Antimicrob Agents Chemother; 1979 Jan; 15(1):119-22. PubMed ID: 426499.
    Abstract:
    The relative efficacy and safety of cephradine and cefazolin were compared in 180 patients with a variety of serious infections caused by susceptible organisms. The patients were randomly assigned to one of two groups of 90 patients each. Most patients received 2 to 4 g per day, administered by intravenous injection in four equally divided doses, for a minimum of 4 days. Based on the clinical and microbiological results, the two cephalosporins were found to be comparable in therapeutic effectiveness. Toxicity was not a problem with either drug.
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