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  • Title: Further studies on a vaccinia virus cytotoxin present in infected cell extracts: identification as surface tubule monomer and possible mode of action.
    Author: Burgoyne RD, Stephen J.
    Journal: Arch Virol; 1979; 59(1-2):107-19. PubMed ID: 426631.
    Abstract:
    A vaccinia virus-specific cytotoxic protein (3--10 X 10(4) daltons) had previously been detected in extracts of infected HeLa cells. In this study the protein has been shown to be a late gene product and a virion component--almost certainly the monomer of the surface tubules of the vaccinia virion. The relationship of this cytotoxin to a number of early vaccinia-induced cytopathic effects was examined: it was not the mediator of vaccinia-induced early cell rounding, did not inhibit protein or RNA synthesis in cell-free systems or intact cells (after uptake-induction by hypertonic MgSO4), or cause the release of beta-glucuronidase from a crude preparation of HeLa cell lysosomes. Its possible role in vaccinia-induced cell degeneration, late in infection, is discussed.
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