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  • Title: [Morphogenesis of experimental emphysema induced by different circulation disorders in the lungs].
    Author: Mavrin VK.
    Journal: Arkh Patol; 1979; 41(1):37-42. PubMed ID: 426639.
    Abstract:
    Pulmonary emphysema was reproduced in 126 rabbits by disorders of circulation in the pulmonary artery system with the development of pre- and postcapillary hypertension and hypovolemia of pulmonary circulation. Under conditions of pulmonary circulation hypertension changes in the lungs initially are of the compensatory-hypertrophic nature: hyperplasia and distention of capillaries, myoelastosis of respiratory bronchioles and closing plates of alveoli, hypertrophy of the muscle wall of arteries and veins. At later intervals (4--12 months), processes of atrophy, sclerosis and inflation develop in the lungs; changes in the lungs acquire the nature of emphysema. Anemia, parenchymal atrophy, sclerosis and inflation develop in the lungs due to a considerable reduction of circulation.
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