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  • Title: Treatment of gonorrheal urethritis with spectinomycin hydrochloride.
    Author: Brown J, Tabert O, Hanna JD, Rentiers PL.
    Journal: Can Med Assoc J; 1974 Jan 19; 110(2):173 passim. PubMed ID: 4272505.
    Abstract:
    One hundred and eighty-seven males with uncomplicated gonorrheal urethritis were treated with spectinomycin hydrochloride in a dosage of 2 g. given intramuscularly. A failure rate of 3.2% was observed and no complications of therapy were encountered. In addition, 310 strains of N. gonorrhoeae were tested for susceptibility to penicillin G and spectinomycin. All strains were sensitive to 20 mug./ml. of spectinomycin and this susceptibility appeared to decrease as penicillin resistance increased. A greater incidence of relative resistance to penicillin G was observed than in similar studies from other Canadian areas.
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