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  • Title: A unique 'leukaemic' T lymphoid cell line: absence of stimulating effect in mixed lymphocyte reaction. Lack of MLR-S in leukaemic T lymphoid cells.
    Author: Han T, Minowada J.
    Journal: Clin Exp Immunol; 1973 Dec; 15(4):535-41. PubMed ID: 4273215.
    Abstract:
    `One-way' mixed lymphocyte reactions between fresh, normal, peripheral blood lymphocytes of human or baboon and irradiated or mitomycin C-treated cultured `leukaemic' T lymphoid cells (MOLT-4) were absent in all of forty-six experiments. In contrast, the lymphocytes from the same donors were significantly stimulated by cultured normal B lymphoid cells (B411-4) or Burkitt's lymphoma B lymphoid cells (B35M) in each instance. Neuraminidase-treated MOLT-4 cells also exerted no stimulating effect on allogeneic lymphocytes. Lack of stimulating effect of MOLT-4 cells suggests the possibility that the MLR-S of leukaemic cells may have been lost or masked during the process of leukaemogenesis or during in vitro cultivation.
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