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  • Title: Isolation and characterization of low-kynureninase mutants of Neurospora crassa.
    Author: Schlitt SC, Lester G, Russell PJ.
    Journal: J Bacteriol; 1974 Mar; 117(3):1117-20. PubMed ID: 4273316.
    Abstract:
    Two kynureninase activities are known in Neurospora crassa, one of which (kynureninase I) is inducible, the other (kynureninase II) being constitutive. A method is described for the isolation of low-kynureninase mutants of N. crassa. When grown on an inducer, the mutants show significantly less kynureninase I activity compared with wild type, whereas constitutive kynureninase II activity is unaffected. Since a low level of kynureninase I activity remains in the mutants examined, the mutations may be in a regulatory gene or genes. Other experiments are described concerning the molecular weights of the two enzymes and the intracellular localization and specificity of kynureninase II.
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