These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Steroid excretion and metabolism by gonadal tissue from a subject with testicular feminization syndrome.
    Author: Lockwood E, Ghosh PC, Pennington GW, Tipton R.
    Journal: J Clin Pathol; 1974 Feb; 27(2):135-9. PubMed ID: 4274832.
    Abstract:
    The initial clinical, pathological, and hormonal investigation of a patient with testicular feminization syndrome is described. Incubation of gonadal tissue with various radioactive substrates, together with the isolation and identification of the resulting metabolites, was demonstrated a high capacity to synthesize testosterone. Two biosynthetic pathways were demonstrated, originating from progesterone and pregnenolone. These are essentially similar to those of the normal adult testes. Low levels of activity were found in the phenolic fractions and no measurable production of oestrone, oestradiol, or oestriol was found.
    [Abstract] [Full Text] [Related] [New Search]