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  • Title: The effect of morphine and some other narcotic analgesics on brain tryptophan concentrations.
    Author: Crossley AW, Slater P.
    Journal: J Neurosci Res; 1979; 4(5-6):423-9. PubMed ID: 42812.
    Abstract:
    An acute dose of morphine increased brain tryptophan in mice. This effect was not prevented by naloxone nor was it produced by other narcotic analgesics. Dextrorphan, but not levorphanol, had a similar effect to morphine. A large dose of tryptophan had no effect on the antinociceptive action of morphine in mice. Morphine increased brain tryptophan in rats. This effect was prevented by naloxone. A large dose of tryptophan antagonised the antinociceptive action of morphine in the rat.
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