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  • Title: Luteinization induced by p-chlorophenylalanine treatment in constant oestrous anovulatory rats.
    Author: Trentini GP, Tima L, De Gaetani CF, Mess B.
    Journal: Steroids Lipids Res; 1974; 5(4):262-7. PubMed ID: 4281945.
    Abstract:
    Luteinization induced by p-chlorophenylalanine (p-CPA) treatment in constant estrous anovulatory rats was investigated. 52 constant estrous anovulatory rats with frontal hypothalamic deafferentation (FHD) or suprachiasmatic lesions (HL) were treated intraperitoneally 4 times, on alternate days, with 300 mg p-CPA/kg. The ovaries showed fresh corpora lutea in 52.5% of FHD rats and in 58.3% of HL rats. Therefore p-CPA was able to permit the release of luteinizing hormone-releasing hormone (LH-RH) in an amount sufficient to induce luteinization throught the depletion of brain serotonin. These results indicate that the serotoninergic mechanism of the hypothalamus and/or the midbrain is an inhibitory mediator for the release of LH-RH, and the ovulation-inducing effect of pinealectomy might be mediated by the central-nervous serotoninergic mechanism.
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