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  • Title: Mediastinal lymph node biopsy in sarcoidosis.
    Author: Mikhail JR, Shepherd M, Mitchell DN.
    Journal: Endoscopy; 1979 Feb; 11(1):5-8. PubMed ID: 428353.
    Abstract:
    Mediastinoscopy, in the skilled hands of a thoracic surgeon has proved to be a safe, cosmetically accepted procedure with negligible complications. It has yielded a high rate of diagnostic lymph node tissue; overall greater than 82% among patients with sarcoidosis, including patients presenting with pulmonary mottling only or with a normal chest radiograph. Among patients with lymphatic tuberculosis it enabled the isolation of human M. tuberculosis following culture of the lymph node removed on Löwenstein-Jensen medium in greater than 79% of cases. A precise histological diagnosis was obtained in all 14 patients presenting with hilar and/or paratracheal lymphadenopathy attributable to malignant disease.
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