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  • Title: Hemadsorption-negative plaque test: new assay for rubella virus revealing a unique interference.
    Author: Marcus PI, Carver DH.
    Journal: Science; 1965 Aug 27; 149(3687):983-6. PubMed ID: 4283964.
    Abstract:
    A simple and rapid plaque procedure has been developed for detecting and accurately assaying rubella virus in a noncytopathic virus-cell relationship. Plaque-formation is based on the development, in individual cells infected with rubella virus, of a unique type of intrinsic interference to infection with Newcastle disease virus. Rubella virus-infected cells challenged with Newcastle disease virus and tested for hemadsorption 15 hours later stand out as hemadsorption-negative areas. Individual living cells infected with rubella virus can be resolved under conditions allowing standard cloning procedures. In principle, the hemadsorption-negative plaque test can be used to search for a new class of noncytopathic, non-hemadsorbing viruses-those that induce an intrinsic interference to infection by any hemadsorbing virus.
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