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  • Title: Potentiating mechanism of bradykinin action on smooth muscle by sulfhydryl compounds.
    Author: Iso T, Nishimura K, Oya M, Iwao J.
    Journal: Eur J Pharmacol; 1979 Mar 01; 54(3):303-5. PubMed ID: 428428.
    Abstract:
    (4R)-3-[(2S)-3-Mercapto-2-methylpropanoyl]-4-thiazolidinecarboxylic acid (YS-980), a potent angiotensin I (AI) converting enzyme inhibitor, inhibited the contractile response of isolated guinea-pig ileum to AI but not to AII, while it potentiated the response to bradykinin. Other sulfhydryl compuonds also produced inhibition of AI action, and the effects were closely correlated with their potentiating activities against bradykinin action. These results suggest that it is mainly inhibition of the enzyme in the tissue which participates in the mechanism of potentiation of kinin action by YS-980.
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