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  • Title: Biosynthesis and composition of histones in Novikoff hepatoma nuclei and nucleoli.
    Author: Hnilica LS, Liau MC, Hurlbert RB.
    Journal: Science; 1966 Apr 22; 152(3721):521-3. PubMed ID: 4286358.
    Abstract:
    Histones were prepared from isolated nuclei and nucleoli of the Novikoff ascitic hepatoma at several time points after the injection of L-lysine uniformly labeled with C(14) into tumor-bearing rats. Amino acid analysis and starch-gel electrophoresis failed to reveal any differences between the nuclear and nucleolar histones, although both fractions were more acidic in composition than calf thymus histones. However, the nucleolar histones were a metabolically distinct fraction, and their rate of synthesis was approximately twice that of the total nuclear histones.
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