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  • Title: On the effect of insulin on glucose-6-phosphate dehydrogenase and fatty acid synthetase activity in mouse liver.
    Author: Kukulansky T, Yagil G.
    Journal: Horm Metab Res; 1979 Jan; 11(1):14-9. PubMed ID: 428904.
    Abstract:
    Regulation of glucose-6-phosphate dehydrogenase and fatty acid synthetase activity in mouse liver is examined in diabetic and normal mice. Up to a 4-fold increase of both enzymes can be observed in streptozotocin diabetic mice when transferred to a fatless, inducing diet. Administration of insulin does not increase enzyme activity at several doses and under a variety of conditions. This is a strong indication that insulin is not a necessary component of the induction system.
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