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  • Title: Peripheral catecholamines and memory: characteristics of syrosingopine-induced amnesia.
    Author: Walsh TJ, Palfai T.
    Journal: Pharmacol Biochem Behav; 1979 Oct; 11(4):449-52. PubMed ID: 42929.
    Abstract:
    The effect of syrosingopine on retention of a passive avoidance trial in mice was investigated. The drug given in doses of 2.5, 4.0 or 6.0 mg/kg 2 hr before training, but not when given 24 or 0.5 hr or immediately after training, resulted in amnesia 7 days later. Dopamine or norepinephrine administered systemically 15 min before to 10 min after training was able to block the syrosingopine-induced amnesia. The role of peripheral catecholamines in memory formation was discussed.
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