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  • Title: The effect of etilefrine (Effortil) on central hemodynamics and aorto-coronary bypass blood flow. A pre-operative study.
    Author: Ekeström S, Liljeqvist L, Lothigius B, Nordhus O.
    Journal: Thorac Cardiovasc Surg; 1979 Oct; 27(5):300-3. PubMed ID: 42988.
    Abstract:
    In an attempt to elucidate the function of an aorto-coronary bypass in patients with coronary artery obliterative disease, intravenous injection of etilefrine was used to bring about variations of central hemodynamics. Etilefrine proved to cause a significant increase of cardiac output (QPA), mean systemic blood pressure and aorto-coronary bypass flow. Calculations of peripheral myocardial resistance showed a rather pronounced decrease in all vascular regions studied. There was no change of central venous pressure. The decrease of the myocardial vascular resistance, as shown by the increase of aorto-coronary bypass flow, is indicative of the myocardial vascular capacity. Hence, it may be of value as a prognostic test.
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