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  • Title: Basis for the acquisition of malignant potential by mouse cells cultivated in vitro.
    Author: Aaronson SA, Todaro GJ.
    Journal: Science; 1968 Nov 29; 162(3857):1024-6. PubMed ID: 4301647.
    Abstract:
    Balb/c mouse embryo lines maintained in culture for over 200 generations under conditions that minimize cell-cell contact do not become tumorigenic. Lines cultivated under conditions where there is extensive cell contact become tumor-producing within 30 generations. The tissue-culture property that correlates best with tumorigenicity is the loss of contact inhibition of cell division.
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