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Title: Antianaphylactic agents. 1. 2-(Acylamino)oxazoles. Author: Ross WJ, Harrison RG, Jolley MR, Neville MC, Todd A, Verge JP, Dawson W, Sweatman WJ. Journal: J Med Chem; 1979 Apr; 22(4):412-7. PubMed ID: 430478. Abstract: The synthesis and biological properties of 35 2-(acylamino)oxazoles are described. The majority of the compounds inhibit the release of slow-reacting substance of anaphylaxis (SRS-A) in vitro from sensitized guinea pig chopped lung. In addition, several of the compounds inhibited the release of SRS-A from passively sensitized human chopped lung and protected guinea pigs from the effects of anaphylaxis in a modified Herxheimer test.[Abstract] [Full Text] [Related] [New Search]