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  • Title: Inhibition of vaccinia virus growth by zinc ions: effects on early RNA and thymidine kinase synthesis.
    Author: Zaslavsky V.
    Journal: J Virol; 1979 Jan; 29(1):405-8. PubMed ID: 430599.
    Abstract:
    Accumulation of thymidine kinase activity in vaccinia virus-infected cells was severely inhibited by zinc ions if the drug was added within 1 h postinfection. If added later, zinc ions had no effect on the enzyme synthesis. A fraction of RNA which is normally synthesized in infected cells, was missing from a proper part of the gradient if the cells were treated with zinc ions within 1 h postinfection (as has been shown by cosedimentation of pulse-labeled RNAs in isokinetic gradients). It is suggested that a transcriptional (or posttranscriptional) step is involved in zinc-caused inhibition of vaccinia virus growth.
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