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  • Title: Effects of cyclic 3',5'-AMP and other adenine nucleotides on the melanophores of the lizard (Anolis carolinensis).
    Author: Hadley ME, Goldman JM.
    Journal: Br J Pharmacol; 1969 Nov; 37(3):650-8. PubMed ID: 4310588.
    Abstract:
    1. Cyclic 3',5'-AMP has been reported to darken skins of the frog, Rana pipiens. This suggests that cyclic 3',5'-AMP may mediate the action of MSH on amphibian chromatophores. Since MSH also darkens skins of the lizard, Anolis carolinensis, we investigated the effects of cyclic 3',5'-AMP and other nucleotides on Anolis melanophores to determine whether cyclic 3',5'-AMP may be the intracellular mediator of hormone action on melanophores of another vertebrate class.2. Cyclic 3',5'-AMP, itself, causes a rapid melanin granule aggregation within melanophores of Anolis. This response is, however, somewhat nonspecific in that both 5'-ATP and 5'-ADP also lighten the skins by aggregating the melanin granules. Another nucleotide, 5'-AMP, darkens the skins by dispersing melanin granules. Cyclic 2',3'-AMP does not darken or lighten Anolis skins.3. Dibutyryl cyclic 3',5'-AMP, which is considered to be better able to penetrate membranes and resist degradation by a specific phosphodiesterase, maximally darkens Anolis skins, as does MSH. This darkening by the potent dibutyryl cyclic 3',5'-AMP suggests that cyclic 3',5'-AMP may be the intracellular mediator of melanin granule dispersion within Anolis melanophores leading to skin darkening.4. Other evidence supporting the first-messenger-second-messenger hypothesis for melanophore regulation is discussed.5. The differences in responses of Anolis melanophores to adenine nucleotides may relate to the ability of these agents to penetrate melanophore membranes; thus, the nucleotides could exert their effects either intracellularly or extracellularly on the plasma membrane.
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