These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: The relationship between glucocorticoid binding and tyrosine aminotransferase induction in hepatoma tissue culture cells.
    Author: Baxter JD, Tomkins GM.
    Journal: Proc Natl Acad Sci U S A; 1970 Mar; 65(3):709-15. PubMed ID: 4315614.
    Abstract:
    Glucocorticoid receptors with many properties suggesting their involvement in the hormonal induction of tyrosine aminotransferase have been detected in rat hepatoma tissue culture cells. These "specific receptors" approach saturation as the steroid concentrations required for maximal induction are reached. Inducer analogs influence cortisol binding to the specific receptors in direct relation to their influence on cortisol induction. The inducer association with and dissociation from specific receptors are rapid enough to account for the kinetics of induction and deinduction. Chromatographic studies suggest the specific receptors bind unaltered dexamethasone and cortisol. "Nonspecific" association of steroids with the cells also occurs and can be distinguished from specific binding.
    [Abstract] [Full Text] [Related] [New Search]