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  • Title: 1,25-dihydroxycholecalciferol: identification of the proposed active form of vitamin D3 in the intestine.
    Author: Norman AW, Myrtle JF, Midgett RJ, Nowicki HG, Williams V, Popják G.
    Journal: Science; 1971 Jul 02; 173(3991):51-4. PubMed ID: 4325863.
    Abstract:
    The major polar metabolite of cholecalciferol (vitamin D(3)) present in chick intestinal mucosa has been chemically characterized by mass spectrometric analysis to have a molecular formula of C(27)H(44)0(3) and a structure of 1,25-dihydroxycholecalciferol. This compound, which is produced in the kidney from 25-hydroxycholecalciferol, has been previously shown to be from 4 to 13 times as active as cholecalciferol in stimulating intestinal calcium transport. 1,25-Dihydroxycholecalciferol (previously designated metabolite 4B in this (laboratory) probably represents the biologically active form of cholecalciferol in the intestine.
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