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  • Title: Strontium induced rickets: metabolic basis.
    Author: Omdahl JL, DeLuca HF.
    Journal: Science; 1971 Nov 26; 174(4012):949-51. PubMed ID: 4330835.
    Abstract:
    Dietary strontium inhibits both the synthesis of 1,25-dihydroxycholecalciferol and intestinal calcium absorption in vitamin D(3)-repleted chicks. 1,25-Dihydroxycholecalciferol restores calcium absorption to normal, while 25-hydroxycholecalciferol is without effect in the strontium-fed chick. It is suggested that strontium induces rickets by blocking the biosynthesis of 1,25-dihydroxycholecalciferol, the metabolically active form of vitamin D in the intestine.
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