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  • Title: Metabolic studies on retinoic acid in the rat.
    Author: Sundaresan PR, Bhagavan HN.
    Journal: Biochem J; 1971 Mar; 122(1):1-4. PubMed ID: 4330965.
    Abstract:
    The nature of metabolites in the urine arising from differentially labelled retinoic acid was investigated after injection of physiological doses into retinol-deficient rats. Distribution of radioactivity after partition of urine into ether-soluble, acidic and water-soluble fractions revealed that there were at least six metabolites in urine. Of these, the major metabolite(s) was one lacking both C-14 and C-15 of retinoic acid. Enzymic or alkaline hydrolysis of acidic and water-soluble fractions did not release any retinoic acid, thus indicating that retinoyl beta-glucuronide was not present in urine in significant amounts.
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