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  • Title: 1,25-dihydroxycholecalciferol: a potent stimulator of bone resorption in tissue culture.
    Author: Raisz LG, Trummel CL, Holick MF, DeLuca HF.
    Journal: Science; 1972 Feb 18; 175(4023):768-9. PubMed ID: 4333399.
    Abstract:
    1,25-Dihydroxycholecalciferol (DHCC), isolated from kidney homogenates incubated with 25-hydroxycholecalciferol (HCC), stimulated the release of previously incorporated (45)45Ca from fetal rat bones in organ culture, at concentrations of 10(-10) to 10(-8)M. The dose response curves for 1,25-DHCC and 25-HCC, the parent compound, are parallel, but 1,25-DHCC is about 100 times as potent on a weight basis. Brief exposure to maximum doses of either agent leads to prolonged bone resorption.
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