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Title: Effects of starvation, refeeding, and fat feeding on adipocyte ghost adenyl cyclase activity. Author: Gorman RR, Tepperman HM, Tepperman J. Journal: J Lipid Res; 1972 Mar; 13(2):276-80. PubMed ID: 4335799. Abstract: Basal adenyl cyclase activity and its response to epinephrine and glucagon were studied in isolated adipocyte ghosts obtained from fed, starved, refed, and fat-diet-adapted rats. Epinephrine stimulation of adenyl cyclase was significantly increased in fasted rats, but the glucagon response did not change. Rats fasted for 48 hr and refed a high carbohydrate, low fat diet for 48 or 96 hr showed no differences from chow-fed animals in either basal or hormone-stimulated adenyl cyclase activity. Rats adapted to a high fat, low carbohydrate diet showed an initial and transitory increase in basal activity but a progressive loss of epinephrine- and glucagon-stimulated enzyme activities. The loss in hormone responsiveness correlated well with a decrease in hormone-stimulated lipolysis of fat pads and was associated with a significant increase in fat cell diameter.[Abstract] [Full Text] [Related] [New Search]